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Review: The Endocannabinoid System: A Discussion by Dr. Sulak

Dr. Sulak considers some unique aspects of the endocannabinoid system.

1. “Cannabinoids help regulate homeostasis at every level of life, from sub-cellular levels to the organism itself.” (1)

2. “One interesting way that endocannabinoids differ from other neurotransmitters is that they transmit information in retrograde. This means that instead of traveling from the presynaptic neuron to the postsynaptic, they can flow the opposite way. Endocannabinoids will travel “upstream” to inform presynaptic neurons when a neuron is firing too quickly.”

3. “Research suggests that we can enhance the endocannabinoid system by supplementing with exogenous cannabinoids. Exogenous cannabinoids can help regulate homeostasis, because we already have the organic infrastructure in place to receive them. For example, when THC connects with the endocannabinoid system, it provides highly effective pain relief. The THC modulates neurological function to reduce pain signals.”

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